Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: Results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial
J. Braun1,*, P. Kästner2, P. Flaxenberg3, J. Währisch3, P. Hanke4, W. Demary5, U. von Hinüber5, K. Rockwitz6, W. Heitz7, U. Pichlmeier8, C. Guimbal-Schmolck8, A. Brandt8, MC-MTX.6/RH Study Group
Arthritis & Rheumatism 2008, 58(1):73-81
Vergleich von MTX in Tablettenform („orale Gabe“) und in Spritzenform („parenterale Gabe“): Bei subkutaner Verabreichung (s.c. = lat. subcutan, Spritze unter die Haut) war bei Patienten mit rheumatoider Arthritis (RA) die Wirksamkeit von MTX im Vergleich zur oralen Gabe höher, zugleich wurde keine erhöhte Rate an Nebenwirkungen beobachtet.
Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature
K Visser and D van der Heijde
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Correspondence to: Dr K Visser, Leiden University Medical Center, Department of Rheumatology, C1-R, PO Box 9600, 2300 RC Leiden, The Netherlands; Email: K.Visser@lumc.nl
Accepted November 17, 2008.
Ann Rheum Dis. 2009 July; 68(7): 1094–1099.
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Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative
K Visser1, W Katchamart2, E Loza3, J A Martinez-Lopez4, C Salliot5, J Trudeau6, C Bombardier2,7, L Carmona4, D van der Heijde1, J W J Bijlsma8, D T Boumpas9, H Canhao10, C J Edwards11, V Hamuryudan12, T K Kvien13, B F Leeb14, E M Martín-Mola15, H Mielants16, U Müller-Ladner17, G Murphy18, M Østergaard19, I A Pereira20, C Ramos-Remus21, G Valentini22, J Zochling23, M Dougados5
Published Online First: 25 November 2008. doi:10.1136/ard.2008.094474